Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Vascular calcification (VC) is regarded as an important pathological change lacking effective
treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic lipid
accumulation, which can progress to nonalcoholic steatohepatitis (NASH). Histone …

Sirtuin 6 (SIRT6) has been in the spotlight of aging research because progeroid phenotypes
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Chromatin relaxation is a prerequisite for the DNA repair machinery to access double-strand
breaks (DSBs). Local histones around the DSBs then undergo prompt changes in …

Abstract Histone deacetylase 6 (HDAC6) mediates DNA damage signaling by regulating the
mismatch repair and nucleotide excision repair pathways. Whether HDAC6 also mediates …