Neuronal cell-type classification: challenges, opportunities and the path forward
Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity—and thereby pave the way for …
believe that the only realistic way to manage this complexity—and thereby pave the way for …
Disentangling neural cell diversity using single-cell transcriptomics
Cellular specialization is particularly prominent in mammalian nervous systems, which are
composed of millions to billions of neurons that appear in thousands of different'flavors' and …
composed of millions to billions of neurons that appear in thousands of different'flavors' and …
The Allen mouse brain common coordinate framework: a 3D reference atlas
Recent large-scale collaborations are generating major surveys of cell types and
connections in the mouse brain, collecting large amounts of data across modalities, spatial …
connections in the mouse brain, collecting large amounts of data across modalities, spatial …
[HTML][HTML] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …
or genetic attributes. To better constrain the definition of neuronal cell types, we …
Remote neuronal activity drives glioma progression through SEMA4F
The tumour microenvironment plays an essential role in malignancy, and neurons have
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …
Hierarchical organization of cortical and thalamic connectivity
The mammalian cortex is a laminar structure containing many areas and cell types that are
densely interconnected in complex ways, and for which generalizable principles of …
densely interconnected in complex ways, and for which generalizable principles of …
Shared and distinct transcriptomic cell types across neocortical areas
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …
functionally distinct areas. To investigate the diversity of cell types across the mouse …
A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut
Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense.
However, the matrix of interactions between arrays of molecularly defined neuron subsets …
However, the matrix of interactions between arrays of molecularly defined neuron subsets …
A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality
Modern genetic approaches are powerful in providing access to diverse cell types in the
brain and facilitating the study of their function. Here, we report a large set of driver and …
brain and facilitating the study of their function. Here, we report a large set of driver and …
[HTML][HTML] Cellular anatomy of the mouse primary motor cortex
An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …