The interactions between cells and their surrounding extracellular matrix (ECM) are dynamic
and play critical roles in cell migration during development, health, and diseases. Recent …

Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal
dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to …

During vertebrate organogenesis, increases in morphological complexity are tightly coupled
to morphogen expression. In this work, we studied how morphogens influence self …

Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell
populations, including a pool of cancer stem cells that express LGR5. Whether these distinct …

The formation of holes in epithelial tissue is essential for development, but it can also be
associated with epithelial barrier dysfunction and cancer progression. Here we show that …

The Poisson's ratio and elastic modulus are two parameters determining the elastic behavior
of biomaterials. While the effects of elastic modulus on the cell response is widely studied …

The increasing popularity of 3D cell culture models is being driven by the demand for more
in vivo-like conditions with which to study the biochemistry and biomechanics of numerous …

Cells attach to the world through either cell-extracellular matrix adhesion or cell-cell
adhesion, and traditional biomaterials imitate the matrix for integrin-based adhesion …

We study wetting droplets formed of active Brownian particles in contact with a repulsive
potential barrier, in a wedge geometry. Our numerical results demonstrate a transition …

Cell migration plays a pivotal role in various biological processes including cancer
dissemination and successful metastasis, where the role of mechanical signals is …