Recent developments on triazole nucleus in anticonvulsant compounds: a review
MX Song, XQ Deng - Journal of enzyme inhibition and medicinal …, 2018 - Taylor & Francis
Epilepsy is one of the common diseases seriously threatening life and health of human.
More than 50 million people are suffering from this condition and anticonvulsant agents are …
More than 50 million people are suffering from this condition and anticonvulsant agents are …
Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine
OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …
biological properties and diverse therapeutic applications in medicinal research. They are …
Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies
The discovery of potent STAT3 inhibitors has gained noteworthy impetus in the last decade.
In line with this trend, considering the proven biological importance of 1, 2, 4-triazoles …
In line with this trend, considering the proven biological importance of 1, 2, 4-triazoles …
Design, synthesis, in silico docking studies and biological evaluation of novel quinoxaline-hydrazide hydrazone-1, 2, 3-triazole hybrids as α-glucosidase inhibitors and …
T Settypalli, VR Chunduri, AK Maddineni… - New Journal of …, 2019 - pubs.rsc.org
A new series of quinoxaline-hydrazidehydrazone-1, 2, 3-triazole hybrids, 14a–j, 15a–j and
16a–e, was designed, synthesized and screened for in vitro α-glucosidase and antioxidant …
16a–e, was designed, synthesized and screened for in vitro α-glucosidase and antioxidant …
Molecular modeling studies and synthesis of novel quinoxaline derivatives with potential anticancer activity as inhibitors of c-Met kinase
HAS Abbas, AR Al-Marhabi, SI Eissa… - Bioorganic & medicinal …, 2015 - Elsevier
In an effort to develop potent anti-cancer agents, we have synthesized some substituted
quinoxaline derivatives. Reaction of 6-bromo-3-methylquinoxalin-2 (1H)-one 1 with aromatic …
quinoxaline derivatives. Reaction of 6-bromo-3-methylquinoxalin-2 (1H)-one 1 with aromatic …
Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives
MH El‐Shershaby, KM El‐Gamal… - Archiv der …, 2021 - Wiley Online Library
Herein, we report the synthesis and in vitro antimicrobial evaluation of novel quinoline
derivatives as DNA gyrase inhibitors. The preliminary antimicrobial activity was assessed …
derivatives as DNA gyrase inhibitors. The preliminary antimicrobial activity was assessed …
Pharmacological profile of quinoxalinone
Quinoxalinone and its derivatives are used in organic synthesis for building natural and
designed synthetic compounds and they have been frequently utilized as suitable skeletons …
designed synthetic compounds and they have been frequently utilized as suitable skeletons …
[HTML][HTML] Design and synthesis of some novel 2-(3-methyl-2-oxoquinoxalin-1 (2H)-yl)-N-(4-(substituted) phenyl) acetamide derivatives for biological evaluation as …
MK Ibrahim, AA Abd-Elrahman, RRA Ayyad… - Bulletin of Faculty of …, 2013 - Elsevier
Abstract A new series of 2-(3-methyl-2-oxoquinoxalin-1 (2H)-yl)-N-(4-substitutedphenyl)
acetamides (2–15 a–c) were designed and synthesized in order to evaluate their …
acetamides (2–15 a–c) were designed and synthesized in order to evaluate their …
Quinoxalin-2(1H)-one derived AMPA-receptor antagonists: Design, synthesis, molecular docking and anticonvulsant activity
AGA El-Helby, RRA Ayyad, K El-Adl… - Medicinal Chemistry …, 2017 - Springer
A new series of 4-acetyl-1-substituted-3, 4-dihydroquinoxalin-2 (1 H)-ones (3–14) were
designed and synthesized in order to evaluate their α-amino-3-hydroxy-5-methyl-4 …
designed and synthesized in order to evaluate their α-amino-3-hydroxy-5-methyl-4 …
Design, molecular docking and synthesis of some novel 4-acetyl-1-substituted-3,4-dihydroquinoxalin-2(1H)-one derivatives for anticonvulsant evaluation as AMPA …
AGA El-Helby, RRA Ayyad, K El-Adl, H Sakr… - Medicinal Chemistry …, 2016 - Springer
A new series of 4-acetyl-1-substituted-3, 4-dihydroquinoxalin-2 (1 H)-ones (2–13) were
designed and synthesized in order to evaluate their AMPA-receptor antagonism as a …
designed and synthesized in order to evaluate their AMPA-receptor antagonism as a …