Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …

The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22
(solute carrier 22) transporter family, has received a great deal of attention because of its …

The SLC22 transporter family consists of more than two dozen members, which are
expressed in the kidney, the liver, and other tissues. Evolutionary analysis indicates that …

The proximal tubule of the kidney plays a crucial role in the renal handling of drugs (eg,
diuretics), uremic toxins (eg, indoxyl sulfate), environmental toxins (eg, mercury, aristolochic …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The human solute carrier (SLC) superfamily of transporters is comprised of over 400
membrane-bound proteins, and plays essential roles in a multitude of physiological and …

A new global pandemic of coronavirus disease 2019 (COVID-19) has resulted in high
mortality and morbidity. Currently numerous drugs are under expedited investigations …

Advances in genomic technologies have led to a wealth of information identifying genetic
polymorphisms in membrane transporters, specifically how these polymorphisms affect drug …

The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …

The members of the organic anion transporter (OAT) family are mainly expressed in kidney,
liver, placenta, intestine, and brain. These transporters play important roles in the disposition …