TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

Autophagy, a conserved catabolic process, plays an immensely significant role in a variety
of diseases. However, whether it imparts a protective function in diseases remains …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Since wild-type p53 is central for maintaining genomic stability and preventing oncogenesis,
its coding gene TP53 is highly mutated in~ 50% of human cancers, and its activity is almost …

Autophagy is a delicate intracellular degradation process that occurs due to diverse stressful
conditions, including the accumulation of damaged proteins and organelles as well as …

Despite the extensive genetic and phenotypic variations present in the different tumors, they
frequently share common metabolic alterations, such as autophagy. Autophagy is a self …

Autophagy is an indispensable mechanism of the eukaryotic cell, facilitating the removal and
renewal of cellular components and thereby balancing the cell's energy consumption and …