Recent efforts in the discovery of urease inhibitor identifications
WQ Song, ML Liu, SY Li, ZP **ao - Current Topics in Medicinal …, 2022 - ingentaconnect.com
Urease is an attractive drug target for designing anti-infective agents against pathogens
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
An overview of the privileged synthetic heterocycles as urease enzyme inhibitors: structure–activity relationship
S Sepehri, M Khedmati - Archiv der Pharmazie, 2023 - Wiley Online Library
Urease is a metalloenzyme including two Ni2+ ions, found in some plants, bacteria, fungi,
microorganisms, invertebrate animals, and animal tissues. Urease acts as a significant …
microorganisms, invertebrate animals, and animal tissues. Urease acts as a significant …
Design and synthesis of novel nitrothiazolacetamide conjugated to different thioquinazolinone derivatives as anti-urease agents
The present article describes the design, synthesis, in vitro urease inhibition, and in silico
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
Design and synthesis of new N-thioacylated ciprofloxacin derivatives as urease inhibitors with potential antibacterial activity
A new series of N-thioacylated ciprofloxacin 3a–n were designed and synthesized based on
Willgerodt–Kindler reaction. The results of in vitro urease inhibitory assay indicated that …
Willgerodt–Kindler reaction. The results of in vitro urease inhibitory assay indicated that …
Optimization, purification, and structure elucidation of anthraquinone pigment derivative from Talaromyces purpureogenus as a novel promising antioxidant …
YA Hasanien, AA Nassrallah, AG Zaki… - Journal of Biotechnology, 2022 - Elsevier
This study aims to investigate the bioproduction and prospective biological applications of a
natural red pigment from Talaromyces purpureogenus AUMC2603. Maximum pigment yield …
natural red pigment from Talaromyces purpureogenus AUMC2603. Maximum pigment yield …
New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies
YM Syam, MM Anwar, SS Abd El-Karim, SA Elseginy… - RSC …, 2021 - pubs.rsc.org
The current work represents the design and synthetic approaches of a new set of
compounds 6–10 bearing the 1, 4-dimethyl-2, 3-dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6 …
compounds 6–10 bearing the 1, 4-dimethyl-2, 3-dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6 …
Computational, in vitro and radiation-based in vivo studies on acetamide quinazolinone derivatives as new proposed purine nucleoside phosphorylase inhibitors for …
The present work describes a quinazolinone-based lead optimization for the development of
novel purine nucleoside phosphorylase (PNP) inhibitors with quinazolinone scaffold …
novel purine nucleoside phosphorylase (PNP) inhibitors with quinazolinone scaffold …
Urease inhibitory potential of pyridine-containing triazolothiadiazole and triazolothiadiazine scaffolds for the treatment of ulceration and kidney stone: in vitro screening, kinetics …
The hyperactivity of urease enzyme leads to various complications including gastritis and
peptic ulcer. A diverse variety of natural and synthetic inhibitors have shown a tremendous …
peptic ulcer. A diverse variety of natural and synthetic inhibitors have shown a tremendous …
Histopathology, pharmacokinetics and estimation of interleukin-6 levels of Moringa oleifera leaves extract-functionalized selenium nanoparticles against rats induced …
EMM Ebrahem, GH Sayed, GNA Gad, KE Anwer… - Cancer …, 2022 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most dangerous cancers in all
the world. This study focused on prevention and therapy of hepatocellular carcinoma (HCC) …
the world. This study focused on prevention and therapy of hepatocellular carcinoma (HCC) …
Conventional and microwave-assisted synthesis, anticancer evaluation, 99mTc-coupling and In-vivo study of some novel pyrazolone derivatives
New pyrazolone derivatives were successfully synthesized by both microwave-assisted and
conventional techniques. Compound 3 (3-(3-Methyl-5-oxo-4, 5-dihydro-1H-pyrazol-1-yl)-3 …
conventional techniques. Compound 3 (3-(3-Methyl-5-oxo-4, 5-dihydro-1H-pyrazol-1-yl)-3 …