Control of protein stability by post-translational modifications
Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …
regulatory domains of target proteins, which control a protein's stability. These regions …
[HTML][HTML] Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
J Zhang, H **ang, J Liu, Y Chen, RR He, B Liu - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy
Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1
as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive …
as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive …
Ubiquitin signaling in cell cycle control and tumorigenesis
Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …
reproduces. The major driving force underlying cell cycle progression is the sequential …
DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21 …
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21 …
Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
The bromodomain and extraterminal (BET) family of proteins comprises four members—
BRD2, BRD3, BRD4 and the testis-specific isoform BRDT—that largely function as …
BRD2, BRD3, BRD4 and the testis-specific isoform BRDT—that largely function as …
Mechanisms and function of substrate recruitment by F-box proteins
S phase kinase-associated protein 1 (SKP1)–cullin 1 (CUL1)–F-box protein (SCF) ubiquitin
ligase complexes use a family of F-box proteins as substrate adaptors to mediate the …
ligase complexes use a family of F-box proteins as substrate adaptors to mediate the …
The cytoprotective role of the Keap1–Nrf2 pathway
An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
RING domain E3 ubiquitin ligases
E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …