Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

The protein triggering receptor expressed on myeloid cells-2 (TREM2) is an
immunomodulatory receptor with a central role in myeloid cell activation and survival. In …

INTRODUCTION Glial cells of the central nervous system (CNS), including astrocytes and
microglia, play critical roles in development, tissue repair, and homeostasis. However …

Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …

SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor
progression. Aberrant glycosylation has been intricately linked with immune escape and …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

Integration of extracellular signals by neurons is pivotal for brain development, plasticity, and
repair. Axon guidance relies on receptor-ligand interactions crosstalking with extracellular …

Co-receptors add complexity to cell-cell signaling systems. The secreted semaphorin 3s
(Sema3s) require a co-receptor, neuropilin (Nrp), to signal through plexin As (PlxnAs) in …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …