[HTML][HTML] Ubc13: the Lys63 ubiquitin chain building machine
Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases
to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory …
to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory …
Enzyme tunnels and gates as relevant targets in drug design
SM Marques, L Daniel, T Buryska… - Medicinal Research …, 2017 - Wiley Online Library
Many enzymes contain tunnels and gates that are essential to their function. Gates
reversibly switch between open and closed conformations and thereby control the traffic of …
reversibly switch between open and closed conformations and thereby control the traffic of …
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler
J Liwocha, DT Krist… - Nature chemical …, 2021 - nature.com
Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin
chain architectures guide the binding events and itineraries of modified substrates. Various …
chain architectures guide the binding events and itineraries of modified substrates. Various …
Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability
PK Shukla, D Sinha, AM Leng, JE Bissell… - Journal of Biological …, 2022 - ASBMB
Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in
transcription, genome maintenance, and proteostasis. The contributions of many conserved …
transcription, genome maintenance, and proteostasis. The contributions of many conserved …
Potential targets of severe acute respiratory syndrome coronavirus 2 of clinical drug fluvoxamine: docking and molecular dynamics studies to elucidate viral action
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has continued evolving for
survival and adaptation by mutating itself into different variants of concern, including …
survival and adaptation by mutating itself into different variants of concern, including …
Covalent inhibition of Ubc13 affects ubiquitin signaling and reveals active site elements important for targeting
Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage
signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of …
signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of …
Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes
KA Welsh, DL Bolhuis, AE Nederstigt, J Boyer… - The EMBO …, 2022 - embopress.org
Polyubiquitination by E2 and E3 enzymes is crucial to cell cycle control, epigenetic
regulation, and development. The hallmark of the E2 family is the ubiquitin (Ub)‐conjugating …
regulation, and development. The hallmark of the E2 family is the ubiquitin (Ub)‐conjugating …
Molecular basis for K63-linked ubiquitination processes in double-strand DNA break repair: A focus on kinetics and dynamics
Cells are exposed to thousands of DNA damage events on a daily basis. This damage must
be repaired to preserve genetic information and prevent development of disease. The most …
be repaired to preserve genetic information and prevent development of disease. The most …
Acetylated ubiquitin modulates the catalytic activity of the E1 enzyme Uba1
RE Lacoursiere, GS Shaw - Biochemistry, 2021 - ACS Publications
Ubiquitin (Ub) signaling requires the covalent passage of Ub among E1, E2, and E3
enzymes. The choice of E2 and E3 enzymes combined with multiple rounds of the cascade …
enzymes. The choice of E2 and E3 enzymes combined with multiple rounds of the cascade …
Structural inscrutabilities of Histone (H2BK123) monoubiquitination: A systematic review
P Yadav, S Tanweer, M Garg, M Verma… - International Journal of …, 2024 - Elsevier
Histone H2B monoubiquitination in budding yeast is a highly conserved post-translational
modification. It is involved in normal functions of the cells like DNA Repair, RNA Pol II …
modification. It is involved in normal functions of the cells like DNA Repair, RNA Pol II …