How to enter a bacterium: bacterial porins and the permeation of antibiotics
Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …
century, infectious diseases have remained a leading cause of death. More specifically …
Plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance
The unprecedented use of antibiotics that led to development of resistance affect human
health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases …
health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases …
Defining new chemical space for drug penetration into Gram-negative bacteria
We live in the era of antibiotic resistance, and this problem will progressively worsen if no
new solutions emerge. In particular, Gram-negative pathogens present both biological and …
new solutions emerge. In particular, Gram-negative pathogens present both biological and …
Membrane-targeting amphiphilic AIE photosensitizer for broad-spectrum bacteria imaging and photodynamic killing of bacteria
H Zhang, C He, L Shen, W Tao, J Zhu, J Song… - Chinese Chemical …, 2023 - Elsevier
An amphiphilic AIE photosensitizer has been successfully developed, which allows for
easily inserting into the bacterial membranes. Binding experiments with phospholipid …
easily inserting into the bacterial membranes. Binding experiments with phospholipid …
Fast bacterial growth reduces antibiotic accumulation and efficacy
Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …
Development of a universal fluorescent probe for gram‐positive bacteria
The rapid and sensitive classification of bacteria is the first step of bacterial community
research and the treatment of infection. Herein, a fluorescent probe BacGO is presented …
research and the treatment of infection. Herein, a fluorescent probe BacGO is presented …
Single-cell microfluidics facilitates the rapid quantification of antibiotic accumulation in Gram-negative bacteria
The double-membrane cell envelope of Gram-negative bacteria is a formidable barrier to
intracellular antibiotic accumulation. A quantitative understanding of antibiotic transport in …
intracellular antibiotic accumulation. A quantitative understanding of antibiotic transport in …
Bacterial response mechanism during biofilm growth on different metal material substrates: EPS characteristics, oxidative stress and molecular regulatory network …
J Wang, G Li, H Yin, T An - Environmental research, 2020 - Elsevier
Overwhelming growth of bacterial biofilms on different metal-based pipeline materials are
intractable and pose a serious threat to public health when tap water flows though these …
intractable and pose a serious threat to public health when tap water flows though these …
Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage
B Zhang, W Phetsang, MRL Stone, S Kc… - Communications …, 2023 - nature.com
Antimicrobial resistance is an urgent threat to human health, and new antibacterial drugs are
desperately needed, as are research tools to aid in their discovery and development …
desperately needed, as are research tools to aid in their discovery and development …
Breaching the barrier: quantifying antibiotic permeability across gram-negative bacterial membranes
The double-membrane cell envelope of Gram-negative bacteria is a sophisticated barrier
that facilitates the uptake of nutrients and protects the organism from toxic compounds. An …
that facilitates the uptake of nutrients and protects the organism from toxic compounds. An …