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Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …
Cell–cell communication: new insights and clinical implications
Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …
behaviors through communication. Cell–cell communication (CCC) is essential for growth …
Custom microfluidic chip design enables cost-effective three-dimensional spatiotemporal transcriptomics with a wide field of view
Spatial transcriptomic techniques offer unprecedented insights into the molecular
organization of complex tissues. However, integrating cost-effectiveness, high throughput, a …
organization of complex tissues. However, integrating cost-effectiveness, high throughput, a …
STOmicsDB: a comprehensive database for spatial transcriptomics data sharing, analysis and visualization
Recent technological developments in spatial transcriptomics allow researchers to measure
gene expression of cells and their spatial locations at the single-cell level, generating …
gene expression of cells and their spatial locations at the single-cell level, generating …
Spatiotemporal omics for biology and medicine
The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …
understanding human life. Nonetheless, understanding the intricate mechanisms through …
[HTML][HTML] Spatially resolved transcriptomics: a comprehensive review of their technological advances, applications, and challenges
The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …
technology, from the invention of the microscope 350 years ago to the recent emergence of …
Map** cells through time and space with moscot
Single-cell genomic technologies enable the multimodal profiling of millions of cells across
temporal and spatial dimensions. However, experimental limitations hinder the …
temporal and spatial dimensions. However, experimental limitations hinder the …
High-sensitive spatially resolved T cell receptor sequencing with SPTCR-seq
Spatial resolution of the T cell repertoire is essential for deciphering cancer-associated
immune dysfunction. Current spatially resolved transcriptomic technologies are unable to …
immune dysfunction. Current spatially resolved transcriptomic technologies are unable to …
Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research
Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation
of the spatial localization of transcripts and related analyses in various applications for …
of the spatial localization of transcripts and related analyses in various applications for …
Spatial multiplexing and omics
Much like solving a game of Clue, understanding physiological mysteries involves
answering who, what, when and where. Multiomics approaches delve into cellular and …
answering who, what, when and where. Multiomics approaches delve into cellular and …