Mechanisms that regulate the function of the selectins and their ligands

D Vestweber, JE Blanks - Physiological reviews, 1999 - journals.physiology.org
Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

[HTML][HTML] CD123 as a therapeutic target in the treatment of hematological malignancies

U Testa, E Pelosi, G Castelli - Cancers, 2019 - mdpi.com
The interleukin-3 receptor alpha chain (IL-3Rα), more commonly referred to as CD123, is
widely overexpressed in various hematological malignancies, including acute myeloid …

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

U Testa, E Pelosi, A Frankel - Biomarker research, 2014 - Springer
Recent studies indicate that abnormalities of the alpha-chain of the interleukin-3 receptor (IL-
3RA or CD123) are frequently observed in some leukemic disorders and may contribute to …

The GM–CSF/IL‐3/IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling

SE Broughton, U Dhagat, TR Hercus… - Immunological …, 2012 - Wiley Online Library
Granulocyte–macrophage colony‐stimulating factor (GM–CSF), interleukin‐3 (IL‐3), and IL‐
5 are members of a discrete family of cytokines that regulates the growth, differentiation …

microRNA-222 controls neovascularization by regulating signal transducer and activator of transcription 5A expression

P Dentelli, A Rosso, F Orso, C Olgasi… - … , and vascular biology, 2010 - ahajournals.org
Objective—Inflammatory stimuli released into atherosclerotic plaque microenvironment
regulate vessel formation by modulating gene expression and translation. microRNAs are a …

Rapidly switchable universal CAR-T cells for treatment of CD123-positive leukemia

S Loff, J Dietrich, JE Meyer, J Riewaldt, J Spehr… - Molecular Therapy …, 2020 - cell.com
Chimeric antigen receptor T cells (CAR-T) targeting CD19 or B cell maturation antigen
(BCMA) are highly effective against B cell malignancies. However, application of CAR-T to …

Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow

PS Frenette, S Subbarao, IB Mazo… - Proceedings of the …, 1998 - pnas.org
The adhesive mechanisms allowing hematopoietic progenitor cells (HPC) homing to the
bone marrow (BM) after BM transplantation are poorly understood. We investigated the role …

Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues

KM Schweitzer, AM Dräger… - … American journal of …, 1996 - pmc.ncbi.nlm.nih.gov
The first step in the homing of hematopoietic progenitor cells (HPCs) from the peripheral
blood to the bone marrow involves an adhesion molecule-dependent contact with human …

Interleukins in atherosclerosis: molecular pathways and therapeutic potential

JH Von der Thüsen, J Kuiper, TJC Van Berkel… - Pharmacological …, 2003 - Elsevier
Interleukins are considered to be key players in the chronic vascular inflammatory response
that is typical of atherosclerosis. Thus, the expression of proinflammatory interleukins and …

IL-3: key orchestrator of inflammation

MJ Podolska, R Grützmann, C Pilarsky… - Frontiers in …, 2024 - frontiersin.org
Interleukin (IL)-3 has long been known for its hematopoietic properties. However, recent
evidence has expanded our understanding of IL-3 function by identifying IL-3 as a critical …