Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Calsequestrin is by far the most abundant Ca2+-binding protein in the sarcoplasmic
reticulum (SR) of skeletal and cardiac muscle. It allows the Ca2+ required for contraction to …

The level of Ca inside the sarcoplasmic reticulum (SR) is an important determinant of
functional activity of the Ca release channel/ryanodine receptor (RyR) in cardiac muscle …

The sarcoplasmic reticulum (SR) provides feedback control required to balance the
processes of calcium storage, release, and reuptake in skeletal muscle. This balance is …

The sarcoplasmic reticulum of skeletal muscle cells is a highly ordered structure consisting
of an intricate network of tubules and cisternae specialized for regulating Ca2+ homeostasis …

The cardiac ryanodine receptor (RyR2) is the sarcoplasmic reticulum (SR) Ca2+ release
channel which is responsible for generation of the cytosolic Ca2+ transient required for …

We provide novel evidence that the sarcoplasmic reticulum calcium binding protein,
calsequestrin, inhibits native ryanodine receptor calcium release channel activity …

Calsequestrin (CS), the major Ca2+‐binding protein in the sarcoplasmic reticulum (SR), is
thought to play a dual role in excitation–contraction coupling: buffering free Ca2+ increasing …

In cardiac muscle, the type-2 ryanodine receptor (RyR2) channel plays a central role in
excitation–contraction coupling. The cardiac action potential triggers a small Ca 2+ influx …

Cardiomyocytes (CMs) are nonregenerative. Self-renewable pluripotent human embryonic
stem cells (hESCs) can differentiate into CMs for cell-based therapies. We recently reported …