Venomics: integrative venom proteomics and beyond
JJ Calvete - Biochemical Journal, 2017 - portlandpress.com
Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …
The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype
Variation in gene regulation is ubiquitous, yet identifying the mechanisms producing such
variation, especially for complex traits, is challenging. Snake venoms provide a model …
variation, especially for complex traits, is challenging. Snake venoms provide a model …
Omics technologies for profiling toxin diversity and evolution in snake venom: impacts on the discovery of therapeutic and diagnostic agents
Snake venoms are primarily composed of proteins and peptides, and these toxins have
developed high selectivity to their biological targets. This makes venoms interesting for …
developed high selectivity to their biological targets. This makes venoms interesting for …
Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake
Background Snake venoms are trophic adaptations that represent an ideal model to
examine the evolutionary factors that shape polymorphic traits under strong natural …
examine the evolutionary factors that shape polymorphic traits under strong natural …
Integrated Venomics and Venom Gland Transcriptome Analysis of Juvenile and Adult Mexican Rattlesnakes Crotalus simus, C. tzabcan, and C. culminatus …
Adult rattlesnakes within genus Crotalus express one of two distinct venom phenotypes, type
I (hemorrhagic) and type II (neurotoxic). In Costa Rican Central American rattlesnake …
I (hemorrhagic) and type II (neurotoxic). In Costa Rican Central American rattlesnake …
The habu genome reveals accelerated evolution of venom protein genes
H Shibata, T Chijiwa, N Oda-Ueda, H Nakamura… - Scientific Reports, 2018 - nature.com
Evolution of novel traits is a challenging subject in biological research. Several snake
lineages developed elaborate venom systems to deliver complex protein mixtures for prey …
lineages developed elaborate venom systems to deliver complex protein mixtures for prey …
Quantity, not quality: rapid adaptation in a polygenic trait proceeded exclusively through expression differentiation
A trait's genomic architecture can affect the rate and mechanism of adaptation, and although
many ecologically-important traits are polygenic, most studies connecting genotype …
many ecologically-important traits are polygenic, most studies connecting genotype …
Comparative venom-gland transcriptomics and venom proteomics of four Sidewinder Rattlesnake (Crotalus cerastes) lineages reveal little differential expression …
Abstract Changes in gene expression can rapidly influence adaptive traits in the early
stages of lineage diversification. Venom is an adaptive trait comprised of numerous toxins …
stages of lineage diversification. Venom is an adaptive trait comprised of numerous toxins …
Comparative venom gland transcriptomics of Naja kaouthia (monocled cobra) from Malaysia and Thailand: elucidating geographical venom variation and insights into …
Background The monocled cobra (Naja kaouthia) is a medically important venomous snake
in Southeast Asia. Its venom has been shown to vary geographically in relation to venom …
in Southeast Asia. Its venom has been shown to vary geographically in relation to venom …
Catch a tiger snake by its tail: Differential toxicity, co-factor dependence and antivenom efficacy in a procoagulant clade of Australian venomous snakes
A paradigm of venom research is adaptive evolution of toxins as part of a predator-prey
chemical arms race. This study examined differential co-factor dependence, variations …
chemical arms race. This study examined differential co-factor dependence, variations …