Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

MicroRNA-based diagnosis and therapy

PTB Ho, IM Clark, LTT Le - International journal of molecular sciences, 2022 - mdpi.com
MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …

A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs

H Yan, Y Wen, Z Tian, N Hart, S Han… - Nature biomedical …, 2023 - nature.com
The use of microRNAs as clinical cancer biomarkers is hindered by the absence of accurate,
fast and inexpensive assays for their detection in biofluids. Here we report a one-step and …

[HTML][HTML] Endometriosis-associated infertility: From pathophysiology to tailored treatment

G Bonavina, HS Taylor - Frontiers in endocrinology, 2022 - frontiersin.org
Despite the clinically recognized association between endometriosis and infertility, the
mechanisms implicated in endometriosis-associated infertility are not fully understood …

miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

Breast milk, a source of beneficial microbes and associated benefits for infant health

KE Lyons, CA Ryan, EM Dempsey, RP Ross, C Stanton - Nutrients, 2020 - mdpi.com
Human breast milk is considered the optimum feeding regime for newborn infants due to its
ability to provide complete nutrition and many bioactive health factors. Breast feeding is …

Extracellular miRNAs: from biomarkers to mediators of physiology and disease

MA Mori, RG Ludwig, R Garcia-Martin, BB Brandão… - Cell metabolism, 2019 - cell.com
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

The potential for microRNA therapeutics and clinical research

J Hanna, GS Hossain, J Kocerha - Frontiers in genetics, 2019 - frontiersin.org
As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the
microRNA (miRNA) class of small RNAs expand its preclinical and clinical research …

Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

[HTML][HTML] miRNAs in cancer (review of literature)

B Smolarz, A Durczyński, H Romanowicz… - International journal of …, 2022 - mdpi.com
MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate
gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the …