Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth
regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …

Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

The axoneme is the main extracellular part of cilia and flagella in eukaryotes. It consists of a
microtubule cytoskeleton, which normally comprises nine doublets. In motile cilia, dynein …

Centrosomes are microtubule-organizing centres of animal cells. They influence the
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …

XRCC4 and XLF are two structurally related proteins that function in DNA double-strand
break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called …

The centrosome acts as the main microtubule-nucleating organelle in animal cells and plays
a critical role in mitotic spindle orientation and in genome stability. Yet, despite its central …