Regulation of gene expression in eukaryotes is an extremely complex process. In this
review, we break down several critical steps, emphasizing new data and techniques that …

Although it was originally believed that enhancers activate only the nearest promoter, recent
global analyses enabled by high-throughput technology suggest that the network of …

Hox proteins are homeodomain transcription factors that diversify serially homologous
segments along the animal body axis, as revealed by the classic bithorax phenotype of …

Hox genes encode homeodomain transcription factors that control morphogenesis and have
established functions in development and evolution. Hox proteins have remained enigmatic …

The Hippo pathway regulates growth through the transcriptional coactivator Yorkie, but how
Yorkie promotes transcription remains poorly understood. We address this by characterizing …

Animals have body parts made of similar cell types located at different axial positions, such
as limbs. The identity and distinct morphology of each structure is often specified by the …

The field of epigenomics has been transformed by chromatin immunoprecipitation
approaches that provide for the localization of a defined protein or posttranslationally …

During interphase, chromatin hosts fundamental cellular processes, such as gene
expression, DNA replication and DNA damage repair. To analyze chromatin on a proteomic …

Simple Summary The cancer genome has been exhaustively studied upon the advent of
Next-Generation Sequencing technologies. Coding and non-coding sequences have been …

Homeodomain proteins are evolutionary conserved proteins present in the entire eukaryote
kingdom. They execute functions that are essential for life, both in develo** and adult …