Multiciliated ependymal cells: an update on biology and pathology in the adult brain

AMR Groh, YL Song, F Tea, B Lu, S Huynh… - Acta …, 2024 - Springer
Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial
barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF …

Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins

L Li, J Ran - Cell Death & Disease, 2024 - nature.com
Cilia are highly conserved eukaryotic organelles that protrude from the cell surface and are
involved in sensory perception, motility, and signaling. Their proper assembly and function …

Two Tetrahymena kinesin-9 family members exhibit slow plus-end-directed motility in vitro

H Ishii, M Yamagishi, J Yajima - Scientific Reports, 2024 - nature.com
The kinesin-9 family comprises two subfamilies specific to ciliated eukaryotic cells, and has
recently attracted considerable attention because of its importance in ciliary bending and …

Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility

C Fang, X Pan, D Li, W Chen, Y Huang, Y Chen… - Journal of Cell …, 2024 - rupress.org
Ciliary beat and intraflagellar transport depend on dynein and kinesin motors. The kinesin-9
family members Kif6 and Kif9 are implicated in motile cilia motilities across protists and …

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid …

E Martínez Duncker Rebolledo, D Chan… - Molecular human …, 2024 - academic.oup.com
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a key role in
providing methyl groups for DNA methylation, including during spermatogenesis. A common …

Generation of morphologically distinct astrocyte subtypes from human iPSCs reveals a link between glial shape, function and reactivity

K O'Toole, L Guetta, P Urbanaviciute, P Suklai… - bioRxiv, 2024 - biorxiv.org
Astrocyte morphology in vivo is heterogeneous across different subtypes and dynamically
changes in response to various stimuli. However, several questions on the mechanistic links …

Loss of Elp3 impairs the maturation tempo of brain ependymal cells

S Tielens, C Boutin, S Huysseune, N Thelen… - bioRxiv, 2025 - biorxiv.org
Conditional deletion of Elp3 in the mouse forebrain leads to microcephaly at birth. In this
study, we demonstrate that these mice also develop postnatal hydrocephalus, associated …

Characterizing the in vitro motor properties of two kinesin-9 family members from Tetrahymena

H Ishii, M Yamagishi, J Yajima - 2024 - researchsquare.com
The kinesin-9 family comprises two subfamilies specific to ciliated eukaryotic cells, and has
recently attracted considerable attention because of its importance in ciliary bending and …