Common coupling map advances GPCR-G protein selectivity

AS Hauser, C Avet, C Normand, A Mancini, A Inoue… - Elife, 2022 - elifesciences.org
Two-thirds of human hormones and one-third of clinical drugs act on membrane receptors
that couple to G proteins to achieve appropriate functional responses. While G protein …

Biomolecule and bioentity interaction databases in systems biology: a comprehensive review

FA Baltoumas, S Zafeiropoulou, E Karatzas… - Biomolecules, 2021 - mdpi.com
Technological advances in high-throughput techniques have resulted in tremendous growth
of complex biological datasets providing evidence regarding various biomolecular …

A multi-dimensional view of context-dependent G protein-coupled receptor function

M Marti-Solano - Biochemical Society Transactions, 2023 - portlandpress.com
G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of
biomolecules to activate intracellular signalling cascades that modulate key aspects of cell …

Arena3Dweb: interactive 3D visualization of multilayered networks

E Karatzas, FA Baltoumas, NA Panayiotou… - Nucleic Acids …, 2021 - academic.oup.com
Efficient integration and visualization of heterogeneous biomedical information in a single
view is a key challenge. In this study, we present Arena3Dweb, the first, fully interactive and …

The European research network on signal transduction (ERNEST): toward a multidimensional holistic understanding of G protein-coupled receptor signaling

ME Sommer, J Selent, J Carlsson… - ACS Pharmacology & …, 2020 - ACS Publications
G protein-coupled receptors (GPCRs) are intensively studied due to their therapeutic
potential as drug targets. Members of this large family of transmembrane receptor proteins …

Toward a comprehensive understanding of alicyclic compounds: Bio-effects perspective and deep learning approach

W Shi, K Lin, Y Zhao, Z Li, T Zhou - Science of The Total Environment, 2024 - Elsevier
The escalating use of alicyclic compounds in modern industrial production has led to a rapid
increase of these substances in the environment, posing significant health hazards …

R4 RGS proteins as fine tuners of immature and mature hematopoietic cell trafficking

KYY Chan, PY Chung, C Zhang… - Journal of Leukocyte …, 2022 - academic.oup.com
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane
receptors. They are involved in almost every physiologic process and consequently have a …

[HTML][HTML] Tanshinone IIA as a therapy for PCOS via FOS/JUN/TP53 axis: Evidence from network pharmacology of Bajitian-Danshen pair

H Liu, J Zhou, J **e, L Fan, Y **a, X Peng, H Du… - Arabian Journal of …, 2024 - Elsevier
Polycystic ovary syndrome (PCOS) is a common disease affecting women of reproductive
age; there is a need for interventions to address this condition. Herein, the network …

GPCR-G protein selectivity–a unified meta-analysis

AS Hauser, C Avet, C Normand, A Mancini, A Inoue… - bioRxiv, 2021 - biorxiv.org
Two-thirds of human hormones and one-third of clinical drugs act on membrane receptors
that couple to G proteins to achieve appropriate functional responses. While G protein …

Allosteric Sites and Allosteric Regulators of G Protein-Coupled Receptors: Gray Cardinals of Signal Transduction

AO Shpakov - Journal of Evolutionary Biochemistry and Physiology, 2023 - Springer
Membrane G protein-coupled receptors (GPCRs) are key components of most eukaryotic
signaling systems, transducing external signals to intracellular effector proteins. Activation of …