Common coupling map advances GPCR-G protein selectivity
Two-thirds of human hormones and one-third of clinical drugs act on membrane receptors
that couple to G proteins to achieve appropriate functional responses. While G protein …
that couple to G proteins to achieve appropriate functional responses. While G protein …
Biomolecule and bioentity interaction databases in systems biology: a comprehensive review
Technological advances in high-throughput techniques have resulted in tremendous growth
of complex biological datasets providing evidence regarding various biomolecular …
of complex biological datasets providing evidence regarding various biomolecular …
A multi-dimensional view of context-dependent G protein-coupled receptor function
M Marti-Solano - Biochemical Society Transactions, 2023 - portlandpress.com
G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of
biomolecules to activate intracellular signalling cascades that modulate key aspects of cell …
biomolecules to activate intracellular signalling cascades that modulate key aspects of cell …
Arena3Dweb: interactive 3D visualization of multilayered networks
Efficient integration and visualization of heterogeneous biomedical information in a single
view is a key challenge. In this study, we present Arena3Dweb, the first, fully interactive and …
view is a key challenge. In this study, we present Arena3Dweb, the first, fully interactive and …
The European research network on signal transduction (ERNEST): toward a multidimensional holistic understanding of G protein-coupled receptor signaling
G protein-coupled receptors (GPCRs) are intensively studied due to their therapeutic
potential as drug targets. Members of this large family of transmembrane receptor proteins …
potential as drug targets. Members of this large family of transmembrane receptor proteins …
Toward a comprehensive understanding of alicyclic compounds: Bio-effects perspective and deep learning approach
W Shi, K Lin, Y Zhao, Z Li, T Zhou - Science of The Total Environment, 2024 - Elsevier
The escalating use of alicyclic compounds in modern industrial production has led to a rapid
increase of these substances in the environment, posing significant health hazards …
increase of these substances in the environment, posing significant health hazards …
R4 RGS proteins as fine tuners of immature and mature hematopoietic cell trafficking
KYY Chan, PY Chung, C Zhang… - Journal of Leukocyte …, 2022 - academic.oup.com
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane
receptors. They are involved in almost every physiologic process and consequently have a …
receptors. They are involved in almost every physiologic process and consequently have a …
[HTML][HTML] Tanshinone IIA as a therapy for PCOS via FOS/JUN/TP53 axis: Evidence from network pharmacology of Bajitian-Danshen pair
H Liu, J Zhou, J **e, L Fan, Y **a, X Peng, H Du… - Arabian Journal of …, 2024 - Elsevier
Polycystic ovary syndrome (PCOS) is a common disease affecting women of reproductive
age; there is a need for interventions to address this condition. Herein, the network …
age; there is a need for interventions to address this condition. Herein, the network …
GPCR-G protein selectivity–a unified meta-analysis
Two-thirds of human hormones and one-third of clinical drugs act on membrane receptors
that couple to G proteins to achieve appropriate functional responses. While G protein …
that couple to G proteins to achieve appropriate functional responses. While G protein …
Allosteric Sites and Allosteric Regulators of G Protein-Coupled Receptors: Gray Cardinals of Signal Transduction
AO Shpakov - Journal of Evolutionary Biochemistry and Physiology, 2023 - Springer
Membrane G protein-coupled receptors (GPCRs) are key components of most eukaryotic
signaling systems, transducing external signals to intracellular effector proteins. Activation of …
signaling systems, transducing external signals to intracellular effector proteins. Activation of …