Somatic mutations are the cause of cancer and have been implicated in other,
noncancerous diseases and aging. While clonally expanded mutations can be studied by …

Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …

Malformations of cortical development (MCD) are neurological conditions involving focal
disruptions of cortical architecture and cellular organization that arise during …

While germline copy-number variants (CNVs) contribute to schizophrenia (SCZ) risk, the
contribution of somatic CNVs (sCNVs)—present in some but not all cells—remains …

The genome of multicellular organisms carries the hereditary information necessary for the
development of all organs and tissues and to maintain function in adulthood. To ensure the …

Germline mutations modulate the risk of develo** schizophrenia (SCZ). Much less is
known about the role of mosaic somatic mutations in the context of SCZ. Deep (239×) whole …

DNA methylation marks have recently been used to build models known as epigenetic
clocks, which predict calendar age. As methylation of cytosine promotes C-to-T mutations …

Computational models that measure biological age and aging rate regardless of
chronological age are called aging clocks. The underlying counting mechanisms of the …

Every cell in the human brain possesses a unique genome that is the product of the
accumulation of somatic mutations starting from the first postzygotic cell division and …

Alzheimer's disease (AD) represents a global health challenge, with an estimated 55 million
people suffering from the non-curable disease across the world. While amyloid-plaques and …