Abstract Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response
element-binding (CREB) family, plays a critical role as a stress-induced transcription factor. It …

Programed cell death plays a key role in promoting human development and maintaining
homeostasis. Ferroptosis is a recently identified pattern of programmed cell death that is …

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid
peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular …

Ferroptosis is a type of regulated cell death characterized by lipid peroxidation and
subsequent damage to the plasma membrane. Here, we report a ferroptosis resistance …

This study describes the identification and target deconvolution of small molecule inhibitors
of oncogenic Yes-associated protein (YAP1)/TAZ activity with potent anti-tumor activity in …

Ferroptosis, a form of programmed cell death characterized by iron-dependent lipid
peroxidation, has recently gained considerable attention in the field of cancer therapy. There …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis
and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of …

Summary Spliceosomal GTPase elongation factor Tu GTP binding domain containing 2
(EFTUD2) is a causative gene for mandibulofacial dysostosis with microcephaly (MFDM) …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming an
increasingly pressing global health challenge, with increasing mortality rates showing an …

Our work aimed to investigate the interactive roles of transforming growth factor β1 (TGF-β1),
ubiquitin-specific-processing protease 7 (USP7), and Yes-associated protein (YAP) in …