Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …

IFN-γ up-regulates MHC class I expression and antigen processing and presentation on
cells, since IFN-γ can induce multiple gene expressions that are related to MHC class I …

T regulatory (Treg) cells were discovered more than 20 years ago and have remained a
topic of intense investigation by immunologists. The initial doubts about their existence were …

The recent discovery of fusion of endoplasmic reticulum membrane with nascent
phagosomes suggests that this peripheral compartment in macrophages and dendritic cells …

Conventionally, MHC class I-restricted antigen (Ag) processing requires the action of the
multimolecular peptide-loading complex within the endoplasmic reticulum (ER). Here we …

The loading of MHC class I molecules with their peptide cargo is undertaken by a
multimolecular peptide loading complex within the endoplasmic reticulum. We show that …

ER-associated degradation (ERAD) is an important component of ER quality control
whereby unwanted proteins that are misfolded, misassembled, or metabolically excessive …