[HTML][HTML] Nanosecond pulsed electric fields depolarize transmembrane potential via voltage-gated K+, Ca2+ and TRPM8 channels in U87 glioblastoma cells

RC Burke, SM Bardet, L Carr, S Romanenko… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Nanosecond pulsed electric fields (nsPEFs) have a variety of applications in the biomedical
and biotechnology industries. Cancer treatment has been at the forefront of investigations …

Design, characterization and experimental validation of a compact, flexible pulsed power architecture for ex vivo platelet activation

AL Garner, A Caiafa, Y Jiang, S Klopman, C Morton… - PLoS …, 2017 - journals.plos.org
Electric pulses can induce various changes in cell dynamics and properties depending upon
pulse parameters; however, pulsed power generators for in vitro and ex vivo applications …

High-voltage 10 ns delayed paired or bipolar pulses for in vitro bioelectric experiments

R Orlacchio, L Carr, C Palego, D Arnaud-Cormos… - …, 2021 - Elsevier
Recent studies proved that classical bio-effects induced by nanosecond pulsed electric field
(nsPEF) can be reduced by the delivery of a negative polarity pulse generated immediately …

A nanosecond pulsed electric field (nsPEF) can affect membrane permeabilization and cellular viability in a 3D spheroids tumor model

L Carr, M Golzio, R Orlacchio, G Alberola… - …, 2021 - Elsevier
Abstract Three-dimensional (3D) cellular models represent more realistically the complexity
of in vivo tumors compared to 2D cultures. While 3D models were largely used in classical …

A photo-controlled, all-solid, and frequency-tunable ultra-wideband pulse generator

X Niu, R Wang, L Zeng, F Liu, Y Gu, J Yao… - Review of Scientific …, 2023 - pubs.aip.org
With the continuous exploration of the bioelectric effect, nanosecond and picosecond pulsed
electric fields used in cancer therapy and drug introduction have attracted great attention. In …

Industrial electronics for biomedicine: A new cancer treatment using electroporation

O Lucia, H Sarnago, T Garcia-Sanchez… - IEEE Industrial …, 2019 - ieeexplore.ieee.org
This article reviewed the application of IEs to biomedicine, with an emphasis on the
practice's potential benefits and necessary collaboration between specialist engineers and …

A compact, high-gain, high-power, ultrawideband microwave pulse compressor using time-reversal techniques

ZB Drikas, BD Addissie, VM Mendez… - IEEE Transactions on …, 2020 - ieeexplore.ieee.org
Generation of high-peak-power, microwave ultrashort pulses (USPs) is desirable for
ultrawideband communications and radar/remote sensing. A variety of microwave USP …

[HTML][HTML] Precise, subnanosecond, and high-voltage switching enabled by gallium nitride electronics integrated into complex loads

JW Simonaitis, B Slayton, Y Yang-Keathley… - Review of Scientific …, 2021 - pubs.aip.org
In this work, we report the use of commercial gallium nitride (GaN) power electronics to
precisely switch complex distributed loads, such as electron lenses and deflectors. This was …

Review of Nanosecond Pulse Generator With High-Power Switching Devices

A Ranjan, A Abhishek, N Kumar… - IEEE Transactions on …, 2024 - ieeexplore.ieee.org
A nanosecond pulse generator (NSPG), with a high peak voltage, short-duration pulsewidth,
high repetition rate, and fast rise/fall times, has gained traction and is now used in several …

High Voltage Generator With Adjustable Delay Between Two Nanosecond Pulses

N Tabcheh, R Orlacchio, V Couderc… - IEEE Photonics …, 2022 - ieeexplore.ieee.org
In this letter, we present the experimental setup of a newly designed, high voltage (up to 10
kV), nanosecond duration pulse generator. Based on the frozen wave concept, the …