The immune system is intimately involved in the pathophysiology of heart failure. However, it
is currently underused as a therapeutic target in the clinical setting. Moreover, the …

Cardiovascular disease is the leading cause of mortality globally with at least 26 million
people worldwide living with heart failure (HF). Metabolism has been an active area of …

Background Metabolic syndrome (MS) occurs when different metabolic and hemodynamic
components change simultaneously, being one of the factors related to high mortality rates …

In addition to the regulation of blood pressure, the renin-angiotensin system (RAS) also
plays a key role in the onset and development of insulin resistance, which is central to …

The pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has
been attributed to its ability to enter through the membrane-bound angiotensin-converting …

Doxorubicin (DOX) stimulates the generation of reactive oxygen species, thereby impairing
mitochondrial functions. Angiotensin-converting enzyme inhibitors (ACEIs) have been …

High-throughput assays capable of quantitating the vast majority of any particular type of
biomolecule within a tissue sample, isolated cells or plasma are now available. In order to …

Metabolic syndrome is a pre-diabetic state characterized by several biochemical and
physiological alterations, including insulin resistance, visceral fat accumulation, and …

This thesis investigates the relationship between selenium levels and heart failure.
Selenium, a crucial micronutrient essential for the normal functioning of several proteins and …

The next generation sequencing technologies have advanced pharmacogenetics by
enabling rapid assessment of the entire exome or even whole genome for associations …