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Opportunities and challenges for machine learning-assisted enzyme engineering
Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …
Atomic Engineering of Single‐Atom Nanozymes for Biomedical Applications
J Shen, J Chen, Y Qian, X Wang, D Wang… - Advanced …, 2024 - Wiley Online Library
Single‐atom nanozymes (SAzymes) showcase not only uniformly dispersed active sites but
also meticulously engineered coordination structures. These intricate architectures bestow …
also meticulously engineered coordination structures. These intricate architectures bestow …
Automated in vivo enzyme engineering accelerates biocatalyst optimization
Achieving cost-competitive bio-based processes requires development of stable and
selective biocatalysts. Their realization through in vitro enzyme characterization and …
selective biocatalysts. Their realization through in vitro enzyme characterization and …
From ground-state to excited-state activation modes: Flavin-dependent “ene”-reductases catalyzed non-natural radical reactions
Conspectus Enzymes are desired catalysts for chemical synthesis, because they can be
engineered to provide unparalleled levels of efficiency and selectivity. Yet, despite the …
engineered to provide unparalleled levels of efficiency and selectivity. Yet, despite the …
Machine learning-guided co-optimization of fitness and diversity facilitates combinatorial library design in enzyme engineering
The effective design of combinatorial libraries to balance fitness and diversity facilitates the
engineering of useful enzyme functions, particularly those that are poorly characterized or …
engineering of useful enzyme functions, particularly those that are poorly characterized or …
Modular Access to Chiral Amines via Imine Reductase-Based Photoenzymatic Catalysis
B Chen, R Li, J Feng, B Zhao, J Zhang… - Journal of the …, 2024 - ACS Publications
The development of catalysts serves as the cornerstone of innovation in synthesis, as
exemplified by the recent discovery of photoenzymes. However, the repertoire of naturally …
exemplified by the recent discovery of photoenzymes. However, the repertoire of naturally …
Biocatalysis for the synthesis of active pharmaceutical ingredients in deep eutectic solvents: state-of-the-art and prospects
Biocatalysis holds immense potential for pharmaceutical development as it enables
synthetic routes to various chiral building blocks with unparalleled selectivity. Therein …
synthetic routes to various chiral building blocks with unparalleled selectivity. Therein …
Navigating the landscape of enzyme design: from molecular simulations to machine learning
J Zhou, M Huang - Chemical Society Reviews, 2024 - pubs.rsc.org
Global environmental issues and sustainable development call for new technologies for fine
chemical synthesis and waste valorization. Biocatalysis has attracted great attention as the …
chemical synthesis and waste valorization. Biocatalysis has attracted great attention as the …
Controlled enzymatic synthesis of oligonucleotides
M Pichon, M Hollenstein - Communications Chemistry, 2024 - nature.com
Oligonucleotides are advancing as essential materials for the development of new
therapeutics, artificial genes, or in storage of information applications. Hitherto, our capacity …
therapeutics, artificial genes, or in storage of information applications. Hitherto, our capacity …
Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis
B Brouwer, F Della-Felice, JH Illies… - Chemical …, 2024 - ACS Publications
Biocatalysis has become an important component of modern organic chemistry, presenting
an efficient and environmentally friendly approach to synthetic transformations. Advances in …
an efficient and environmentally friendly approach to synthetic transformations. Advances in …