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[HTML][HTML] A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway
WP Steiner, N Iverson, V Venkatakrishnan, J Wu… - …, 2024 - pmc.ncbi.nlm.nih.gov
The Hedgehog (Hh) signaling pathway is fundamental to embryogenesis, tissue
homeostasis, and cancer. Hh signals are transduced via an unusual mechanism: upon …
homeostasis, and cancer. Hh signals are transduced via an unusual mechanism: upon …
Cryo-EM reveals a phosphorylated R-domain envelops the NBD1 catalytic domain in an ABC transporter
Many ATP-binding cassette transporters are regulated by phosphorylation on long and
disordered loops which presents a challenge to visualize with structural methods. We have …
disordered loops which presents a challenge to visualize with structural methods. We have …