Finding strategies against the development of antibiotic resistance is a major global
challenge for the life sciences community and for public health. The past decades have seen …

Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

Natural product drug discovery has regained interest due to low production costs, structural
diversity, and multiple uses of active compounds to treat various diseases. Attention has …

We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

The molecular mechanisms determining the transmissibility and prevalence of drug-resistant
tuberculosis in a population were investigated through whole-genome sequencing of 1,000 …

There is a lack of new antibiotics to combat drug-resistant bacterial infections that
increasingly threaten global health. The current pipeline of clinical-stage antimicrobials is …

Allosteric transcription factors (aTFs) have proven widely applicable for biotechnology and
synthetic biology as ligand-specific biosensors enabling real-time monitoring, selection and …

Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly,
multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now …

Anti-tuberculosis drugs are a two-edged sword. While they destroy pathogenic M.
tuberculosis they also select for drug resistant bacteria against which those drugs are then …

Tuberculosis is a major disease causing every year 1.8 million deaths worldwide and
represents the leading cause of mortality resulting from a bacterial infection. Introduction in …