The fascinating patterns of collective motion created by autonomously driven particles have
fuelled active-matter research for over two decades. So far, theoretical active-matter …

Active matter, which ranges from molecular motors to groups of animals, exists at different
length scales and timescales, and various computational models have been proposed to …

Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch
between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell …

Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Pathological morphological changes in tumor tissue enable collective cancer cell
unjamming, a cellular motility transition. However, fundamental questions remain: Is …

The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …

Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …

The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

A passive solid cannot do work on its surroundings through any quasistatic cycle of
deformations. This property places strong constraints on the allowed elastic moduli. In this …

Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …