Evidence has emerged in the last two decades that at the molecular level most chronic
diseases, including cancer, are caused by a dysregulated inflammatory response. The …

There is evidence supporting the hypothesis that inflammation participates in providing
conditions that lead to cancer. An unresolved inflammation due to any failure in the precise …

Angiogenesis is an important host process that interacts with cancer cells to promote growth,
invasion, and metastasis. Numerous therapeutic agents targeting the VEGF pathway have …

OBJECTIVE: The vascular endothelial growth factor (VEGF) is an important regulator of
angiogenesis and vascular permeability of tumors. In the present study we evaluated the …

Context: Tumor angiogenesis is determined by host genetic background rather than
environment. Germline single nucleotide polymorphisms (SNPs) of the vascular endothelial …

Angiogenesis is essential for growth, progression, and metastasis of solid tumors. Vascular
endothelial growth factor (VEGF)/VEGF receptor (VEGFR) and angiopoietin …

Purpose Bevacizumab and chemotherapy is a common choice for first-line treatment of
metastatic colorectal cancer (mCRC). So far, no predictive markers have been identified …

BACKGROUND AND AIMS: Interleukin-23 (IL-23) has a role in inflammatory bowel diseases
(IBD) as a condition of higher risk of colorectal carcinogenesis. Vascular endothelial growth …

Purpose: Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular
permeability. The VEGF gene is polymorphic. We investigated the prognostic significance of …

Purpose: Vascular endothelial cell growth factor is studied in different malignant tumors as a
key endothelial cell mitogen. Many single nucleotide polymorphisms in the VEGF gene have …