Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Abstract γδ T cells play uniquely important roles in stress surveillance and immunity for
infections and carcinogenesis. Human γδ T cells recognize and kill transformed cells …

In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells
through an 'inside out'signalling process whereby structurally diverse phosphoantigen (pAg) …

INTRODUCTION T cells represent a key component of the immune system that can
recognize foreign molecules (antigens) via cognate cell surface receptors termed T cell …

Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC),
yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both …

Abstract Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. Due to
their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for …

Immune checkpoint blockade has been largely unsuccessful for the treatment of bone
metastatic castrate-resistant prostate cancer (mCRPC). Here, we report a combinatorial …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

A growing number of studies have shown that γδ T cells play a pivotal role in mediating the
clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …