Epigenetic therapies for cancer
SE Bates - New England Journal of Medicine, 2020 - Mass Medical Soc
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Cutaneous T cell lymphoma
R Dummer, MH Vermeer, JJ Scarisbrick… - Nature Reviews …, 2021 - nature.com
Primary cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphomas
that present in the skin with no evidence of extracutaneous disease at the time of diagnosis …
that present in the skin with no evidence of extracutaneous disease at the time of diagnosis …
Landscape of microsatellite instability across 39 cancer types
Purpose Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …
JAK inhibitors in dermatology: the promise of a new drug class
W Damsky, BA King - Journal of the American Academy of Dermatology, 2017 - Elsevier
New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
TL Song, ML Nairismägi, Y Laurensia… - Blood, The Journal …, 2018 - ashpublications.org
Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal
NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas …
NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas …
Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine
carcinoma, associated with the Merkel cell polyomavirus (MCPyV) in 80% of cases. To …
carcinoma, associated with the Merkel cell polyomavirus (MCPyV) in 80% of cases. To …
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL)
resulting from the malignant transformation of skin-homing central memory CD4+ T cells …
resulting from the malignant transformation of skin-homing central memory CD4+ T cells …
PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma
The PDCD1-encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells
that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). The highest …
that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). The highest …
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …
Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling
Y Watatani, Y Sato, H Miyoshi, K Sakamoto, K Nishida… - Leukemia, 2019 - nature.com
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of
exclusion, being the most common entity in mature T-cell neoplasms, and its molecular …
exclusion, being the most common entity in mature T-cell neoplasms, and its molecular …