Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling
pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an …

Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …

Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …

Transit-amplifying cells (TACs) are an early intermediate in tissue regeneration. Here, using
hair follicles (HFs) as a paradigm, we show that emerging TACs constitute a signaling center …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

The skin constantly renews itself throughout adult life, and the hair follicle undergoes a
perpetual cycle of growth and degeneration. Stem cells (SCs) residing in the epidermis and …

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during
embryonic development and adult tissue homeostasis. Here we review the current …

Abstract Three-dimensional (3D) protein-patterned scaffolds provide a more biomimetic
environment for cell culture than traditional two-dimensional surfaces, but simultaneous 3D …

In adult skin, stem cells in the hair follicle bulge cyclically regenerate the follicle, whereas a
distinct stem cell population maintains the epidermis. The degree to which all bulge cells …

Abstract Tissue-engineered skin (TES), as an analogue of native skin, is promising for
wound repair and regeneration. However, a major drawback of TES products is a lack of …