Reactive astrogliosis, whereby astrocytes undergo varying molecular and morphological
changes, is a ubiquitous but poorly understood hallmark of all central nervous system …

Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

Astrocytes are the most populous glial cells in the central nervous system (CNS). They are
essential to CNS physiology and play important roles in the maintenance of homeostasis …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Astrocyte-like cells, which act as stem cells in the adult brain, reside in a few restricted stem
cell niches. However, following brain injury, glia outside these niches acquire or reactivate …

Background Glioblastoma multiforme (GBM) is an umbrella designation that includes a
heterogeneous group of primary brain tumors. Several classification strategies of GBM have …

Long considered merely a trophic and mechanical support to neurons, astrocytes have
progressively taken the center stage as their ability to react to acute and chronic …

Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex
pathological mechanisms that leads to sensory and motor dysfunction. The current treatment …

Glial scarring following severe tissue damage and inflammation after spinal cord injury (SCI)
is due to an extreme, uncontrolled form of reactive astrogliosis that typically occurs around …

The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and
belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR …