Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR
superfamily—have several atypical characteristics, including large, multi-domain N termini …

The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone
receptors, a sub-group of class A G-protein-coupled receptors (GPCRs). TSHR and its …

The activity of the thyroid gland is predominantly regulated by the concentration of the
pituitary glycoprotein hormone, thyroid-stimulating hormone (TSH). In the absence of the …

Determination of the full-length thyroid-stimulating hormone receptor (TSHR) structure by
cryo-electron microscopy (cryo-EM) is described. The TSHR complexed with human …

ABSTRACT Introduction: Graves' disease (GD) and thyroid-associated ophthalmopathy
(TAO) are thought to result from actions of pathogenic antibodies mediated through the …

Graves' disease (GD) is an organ-specific autoimmune disease, and thyrotropin (TSH)
receptor (TSHR) is a major autoantigen in this condition. Since the extracellular domain of …

Pathological activation of the thyroid-stimulating hormone receptor (TSHR) is caused by
thyroid-stimulating antibodies in patients with Graves' disease (GD) or by somatic and rare …

G protein coupled receptors (GPCRs) can lead to G protein and non-G protein initiated
signals. By virtue of its structural property, the TSH receptor (TSHR) has a unique ability to …

Purpose The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for
TSHR-stimulating autoantibodies in Graves' disease. The TSHR is composed of: a leucine …

The large TSH-bound ectodomain of the thyrotropin receptor (TSHR) activates the
transmembrane domain (TMD) indirectly via an internal agonist (IA). The ectodomain/TMD …