NMR solution structures of stereoisomeric covalent polycyclic aromatic carcinogen− DNA adducts: principles, patterns, and diversity
NE Geacintov, M Cosman, BE Hingerty… - Chemical research in …, 1997 - ACS Publications
Exogenous chemicals have been implicated in causing mutations that are responsible for
the initiation and progression of tumors (1r5). Mutations in the p53 gene, a tumor suppressor …
the initiation and progression of tumors (1r5). Mutations in the p53 gene, a tumor suppressor …
Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites
RH Heflich, RE Neft - Mutation Research/Reviews in Genetic Toxicology, 1994 - Elsevier
Acetylaminofluorene and 2-aminofluorene are among the most intensively studied of all
chemical mutagens and carcinogens. Fundamental research findings concerning the …
chemical mutagens and carcinogens. Fundamental research findings concerning the …
NMR structures of damaged DNA
M Lukin, C de Los Santos - Chemical reviews, 2006 - ACS Publications
Attesting to the spectacular growth in the field of structural biology, the total number of
coordinate files deposited in the Protein Data Bank was rapidly approaching 30 000 entries …
coordinate files deposited in the Protein Data Bank was rapidly approaching 30 000 entries …
Mechanisms of frameshift mutations: insight from aromatic amines
GR Hoffmann, RPP Fuchs - Chemical research in toxicology, 1997 - ACS Publications
This perspective explores mechanisms of frameshift mutagenesis as revealed by studies of
selected aromatic amines and amides. The data are drawn primarily from studies of three …
selected aromatic amines and amides. The data are drawn primarily from studies of three …
Repair-resistant DNA lesions
The eukaryotic global genomic nucleotide excision repair (GG-NER) pathway is the major
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …
A model for initial DNA lesion recognition by NER and MMR based on local conformational flexibility
RJ Isaacs, HP Spielmann - DNA repair, 2004 - Elsevier
Initial recognition of DNA damage is the crucial but poorly understood first step in DNA
repair by the human nucleotide excision repair (NER) and mismatch repair (MMR) systems …
repair by the human nucleotide excision repair (NER) and mismatch repair (MMR) systems …
Nucleotide excision repair of 2-acetylaminofluorene-and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and …
H Mu, K Kropachev, L Wang, L Zhang… - Nucleic acids …, 2012 - academic.oup.com
Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of
magnitude, for reasons that remain unclear. An example is the pair of N-(2′-deoxyguanosin …
magnitude, for reasons that remain unclear. An example is the pair of N-(2′-deoxyguanosin …
Kinetics of DNA Polymerase I (Klenow Fragment Exo-) Activity on Damaged DNA Templates: Effect of Proximal and Distal Template Damage on DNA Synthesis
Mutagenic DNA adducts have been analyzed with respect to the rate of nucleotide insertion
opposite the modified base, extension from that “mispair”, and nucleotide insertion …
opposite the modified base, extension from that “mispair”, and nucleotide insertion …
[HTML][HTML] Acrolein-and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells
Tobacco smoke (TS) is a major cause of human bladder cancer (BC). Two components in
TS, 4-aminobiphenyl (4-ABP) and acrolein, which also are environmental contaminants, can …
TS, 4-aminobiphenyl (4-ABP) and acrolein, which also are environmental contaminants, can …