Tumor cells evolve in a complex and heterogeneous environment composed of different cell
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …

In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …

Background Relapse and metastasis in colorectal cancer (CRC) are often attributed to
cancer stem-like cells (CSCs), as small sub-population of tumor cells with ability of drug …

The tumor microenvironment consists of diverse, complex etiological factors. The matrix
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …

The use of mesenchymal stem cells (MSCs) for clinical purposes has skyrocketed in the past
decade. Their multilineage differentiation potentials and immunomodulatory properties have …

Two-dimensional (2D) cell cultures have been the standard for many different applications,
ranging from basic research to stem cell and cancer research to regenerative medicine, for …

Cardiac organoids are 3-dimensional (3D) structures composed of tissue or niche-specific
cells, obtained from diverse sources, encapsulated in either a naturally derived or synthetic …

Nanomedicine has emerged as a promising therapeutic approach, but its translation to the
clinic has been hindered by the lack of cellular models to anticipate how tumor cells will …

Carmustine (BCNU) is a typical chemotherapy used for treatment of cerebroma and other
solid tumors, which exerts antitumor effect by inducing DNA damage at O 6 position of …

In continuation of our previous studies, we developed polymeric epigallocatechin 3-gallate
(EGCG)-loaded nanoparticles (NPs) coupled with folic acid (FA), able to dually bind the …