AMPK signaling pathway as a potential therapeutic target for Parkinson's disease

SZ Athari, F Farajdokht… - Advanced …, 2023 - pmc.ncbi.nlm.nih.gov
Parkinson's disease (PD) is the second most common neurodegenerative disease caused
by the loss of dopaminergic neurons. Genetic factors, inflammatory responses, oxidative …

Treatment of Parkinson's disease with biologics that penetrate the blood–brain barrier via receptor-mediated transport

WM Pardridge - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Parkinson's disease (PD) is characterized by neurodegeneration of nigral-striatal neurons in
parallel with the formation of intra-neuronal α-synuclein aggregates, and these processes …

Microglia Signaling in Health and Disease–Implications in Sex-Specific Brain Development and Plasticity

S Pramanik, MH Devi, S Chakrabarty, B Paylar… - Neuroscience & …, 2024 - Elsevier
Microglia, the intrinsic neuroimmune cells residing in the central nervous system (CNS),
exert a pivotal influence on brain development, homeostasis, and functionality …

Tilorone mitigates the propagation of α-synucleinopathy in a midbrain-like organoid model

Q Zhang, M Liu, Y Xu, J Lee, B Jones, B Li… - Journal of Translational …, 2024 - Springer
Background Parkinson's disease (PD) is a neurodegenerative condition characterized by
the loss of dopaminergic neurons and the accumulation of Lewy-body protein aggregates …

Hydrophobic Carbon Dots Prevent α‐Synucleinopathy and Suppress Neuroinflammation to Treat Parkinson's Disease

L Li, Y Lu, X Ye, C Zhang, J Liu, Z Yang, J Hao - Aggregate, 2024 - Wiley Online Library
The aggregation of α‐synuclein (ɑ‐syn) coupled with overexpressed neuroinflammation
instigates the degeneration of dopaminergic neurons, thereby aggravating the progression …

[HTML][HTML] Microbiota Orchestra in Parkinson's Disease: The Nasal and Oral Maestros

N Rei, M Grunho, JJ Mendes, J Fonseca - Biomedicines, 2024 - mdpi.com
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic
neurons, leading to a range of motor and non-motor symptoms. Background/Objectives …

α‐Synuclein in Parkinson's Disease: From Bench to Bedside

G Bellini, V D'Antongiovanni, G Palermo… - Medicinal Research …, 2024 - Wiley Online Library
ABSTRACT α‐Synuclein (α‐syn), a pathological hallmark of PD, is emerging as a bridging
element at the crossroads between neuro/immune‐inflammatory responses and …

Identifying NFKB1, STAT3, and CDKN1A as Baicalein's Potential Hub Targets in Parkinson's Disease-related α-synuclein-mediated Pathways by Integrated …

X Li, Q Deng, Y Kuang, H Mao, M Yao… - Current …, 2023 - ingentaconnect.com
Background: The overexpression, accumulation, and cell-to-cell transmission of α-synuclein
leads to the deterioration of Parkinson's disease (PD). Previous studies suggest that …

Comprehensive analysis of an endoplasmic reticulum stress-related gene prediction model and immune infiltration in idiopathic pulmonary fibrosis

H Zhu, A Zhou, M Zhang, L Pan, X Wu, C Fu… - Frontiers in …, 2024 - frontiersin.org
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung
disease. This study aimed to investigate the involvement of endoplasmic reticulum stress …

Lipids and α-Synuclein: adding further variables to the equation

J Schepers, T Löser, C Behl - Frontiers in Molecular Biosciences, 2024 - frontiersin.org
Aggregation of alpha-Synuclein (αSyn) has been connected to several neurodegenerative
diseases, such as Parkinson's disease (PD), dementia with Lewy Bodies (DLB), and multiple …