AMPK signaling pathway as a potential therapeutic target for Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disease caused
by the loss of dopaminergic neurons. Genetic factors, inflammatory responses, oxidative …
by the loss of dopaminergic neurons. Genetic factors, inflammatory responses, oxidative …
Treatment of Parkinson's disease with biologics that penetrate the blood–brain barrier via receptor-mediated transport
WM Pardridge - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Parkinson's disease (PD) is characterized by neurodegeneration of nigral-striatal neurons in
parallel with the formation of intra-neuronal α-synuclein aggregates, and these processes …
parallel with the formation of intra-neuronal α-synuclein aggregates, and these processes …
Microglia Signaling in Health and Disease–Implications in Sex-Specific Brain Development and Plasticity
Microglia, the intrinsic neuroimmune cells residing in the central nervous system (CNS),
exert a pivotal influence on brain development, homeostasis, and functionality …
exert a pivotal influence on brain development, homeostasis, and functionality …
Tilorone mitigates the propagation of α-synucleinopathy in a midbrain-like organoid model
Q Zhang, M Liu, Y Xu, J Lee, B Jones, B Li… - Journal of Translational …, 2024 - Springer
Background Parkinson's disease (PD) is a neurodegenerative condition characterized by
the loss of dopaminergic neurons and the accumulation of Lewy-body protein aggregates …
the loss of dopaminergic neurons and the accumulation of Lewy-body protein aggregates …
Hydrophobic Carbon Dots Prevent α‐Synucleinopathy and Suppress Neuroinflammation to Treat Parkinson's Disease
The aggregation of α‐synuclein (ɑ‐syn) coupled with overexpressed neuroinflammation
instigates the degeneration of dopaminergic neurons, thereby aggravating the progression …
instigates the degeneration of dopaminergic neurons, thereby aggravating the progression …
[HTML][HTML] Microbiota Orchestra in Parkinson's Disease: The Nasal and Oral Maestros
N Rei, M Grunho, JJ Mendes, J Fonseca - Biomedicines, 2024 - mdpi.com
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic
neurons, leading to a range of motor and non-motor symptoms. Background/Objectives …
neurons, leading to a range of motor and non-motor symptoms. Background/Objectives …
α‐Synuclein in Parkinson's Disease: From Bench to Bedside
ABSTRACT α‐Synuclein (α‐syn), a pathological hallmark of PD, is emerging as a bridging
element at the crossroads between neuro/immune‐inflammatory responses and …
element at the crossroads between neuro/immune‐inflammatory responses and …
Identifying NFKB1, STAT3, and CDKN1A as Baicalein's Potential Hub Targets in Parkinson's Disease-related α-synuclein-mediated Pathways by Integrated …
X Li, Q Deng, Y Kuang, H Mao, M Yao… - Current …, 2023 - ingentaconnect.com
Background: The overexpression, accumulation, and cell-to-cell transmission of α-synuclein
leads to the deterioration of Parkinson's disease (PD). Previous studies suggest that …
leads to the deterioration of Parkinson's disease (PD). Previous studies suggest that …
Comprehensive analysis of an endoplasmic reticulum stress-related gene prediction model and immune infiltration in idiopathic pulmonary fibrosis
H Zhu, A Zhou, M Zhang, L Pan, X Wu, C Fu… - Frontiers in …, 2024 - frontiersin.org
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung
disease. This study aimed to investigate the involvement of endoplasmic reticulum stress …
disease. This study aimed to investigate the involvement of endoplasmic reticulum stress …
Lipids and α-Synuclein: adding further variables to the equation
J Schepers, T Löser, C Behl - Frontiers in Molecular Biosciences, 2024 - frontiersin.org
Aggregation of alpha-Synuclein (αSyn) has been connected to several neurodegenerative
diseases, such as Parkinson's disease (PD), dementia with Lewy Bodies (DLB), and multiple …
diseases, such as Parkinson's disease (PD), dementia with Lewy Bodies (DLB), and multiple …