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Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors
MZ Khan, L He - Psychopharmacology, 2017 - Springer
Background In the central nervous system (CNS), G protein-coupled receptors (GPCRs) are
the most fruitful targets for neuropsychopharmacological drug development. Rhodopsin …
the most fruitful targets for neuropsychopharmacological drug development. Rhodopsin …
Orphan receptor GPR88 as an emerging neurotherapeutic target
Although G protein-coupled receptors (GPCRs) are recognized as pivotal drug targets
involved in multiple physiological and pathological processes, the majority of GPCRs …
involved in multiple physiological and pathological processes, the majority of GPCRs …
Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research
Orphan G-protein-coupled receptors (oGPCRs) possess untapped potential for drug
discovery. In the brain, oGPCRs are generally expressed at low abundance and their …
discovery. In the brain, oGPCRs are generally expressed at low abundance and their …
Increased alcohol seeking in mice lacking Gpr88 involves dysfunctional mesocorticolimbic networks
Backgound Alcohol use disorder (AUD) is devastating and poorly treated, and innovative
targets are actively sought for prevention and treatment. The orphan G protein–coupled …
targets are actively sought for prevention and treatment. The orphan G protein–coupled …
The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs
GPR88 is an orphan G protein-coupled receptor (GPCR) considered as a promising
therapeutic target for neuropsychiatric disorders; its pharmacology, however, remains …
therapeutic target for neuropsychiatric disorders; its pharmacology, however, remains …
Discovery of a potent, selective, and brain-penetrant small molecule that activates the orphan receptor GPR88 and reduces alcohol intake
C **, AM Decker, VH Makhijani… - Journal of medicinal …, 2018 - ACS Publications
The orphan G-protein-coupled receptor GPR88 is highly expressed in the striatum. Studies
using GPR88 knockout mice have suggested that the receptor is implicated in alcohol …
using GPR88 knockout mice have suggested that the receptor is implicated in alcohol …
Molecular insights into orphan G protein‐coupled receptors relevant to schizophrenia
Schizophrenia remains a sizable socio‐economic burden that continues to be treated with
therapeutics based on 70‐year old science. All currently approved therapeutics primarily …
therapeutics based on 70‐year old science. All currently approved therapeutics primarily …
The orphan receptor GPR88 controls impulsivity and is a risk factor for attention-deficit/hyperactivity disorder
S Ben Hamida, SM Sengupta, E Clarke… - Molecular …, 2022 - nature.com
The neural orphan G protein coupled receptor GPR88 is predominant in the striatum and
cortex of both rodents and humans, and considered a potential target for brain disorders …
cortex of both rodents and humans, and considered a potential target for brain disorders …
Map** GPR88-Venus illuminates a novel role for GPR88 in sensory processing
AT Ehrlich, M Semache, J Bailly, S Wojcik… - Brain Structure and …, 2018 - Springer
GPR88 is an orphan G-protein coupled receptor originally characterized as a striatal-
enriched transcript and is a potential target for neuropsychiatric disorders. At present, gene …
enriched transcript and is a potential target for neuropsychiatric disorders. At present, gene …
Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice
Recent studies have demonstrated that orchestrated gene activity and expression support
synchronous activity of brain networks. However, there is a paucity of information on the …
synchronous activity of brain networks. However, there is a paucity of information on the …