Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines
in skeletal muscle mitochondria are thought to play a primary role in this process …

Ageing—the decline in survival and fecundity with advancing age—is caused by damage to
macromolecules and tissues. Ageing is not a programmed process, in the sense that no …

Mitochondria are negatively affected by ageing leading to their inability to adapt to higher
levels of oxidative stress and this ultimately contributes to the systemic loss of muscle mass …

Calorie-restricted feeding retards the rate of ageing in mammalian and invertebrate species.
The molecular mechanisms underlying this effect include a lower rate of accrual of tissue …

Mitochondria are a cell's single greatest source of reactive oxygen species. Reactive oxygen
species are important for many life sustaining processes of cells and tissues, but they can …

SUMMARY A negative intraspecific relationship between growth and longevity was
proposed in the early 20th century. Indeed, stunting the growth of rodents by restricting their …

Sarcopenia, the loss of muscle mass and function, is a common feature of aging and impacts
on individual health and quality of life. Several cellular mechanisms have been involved in …

Accumulated oxidative stress resulting from a gradual shift in the redox status of tissues is
now considered to be a key mechanism underlying the aging process. Calorie‐restricted …

Energy restriction (ER), without malnutrition, increases maximum life span and retards the
development of a broad array of pathophysiological changes in laboratory rodents. The …