Centrosomes are the primary microtubule organizer in eukaryotic cells. In addition to
sha** the intracellular microtubule network and the mitotic spindle, centrosomes are …

An abnormal chromosome number, or aneuploidy, underlies developmental disorders and
is a common feature of cancer, with different cancer types exhibiting distinct patterns of …

Culture-acquired variants in human pluripotent stem cells (hPSCs) hinder their applications
in research and clinic. However, the mechanisms that underpin selection of variants remain …

Although implicated as deleterious in many organisms, aneuploidy can underlie rapid
phenotypic evolution. However, aneuploidy will be maintained only if the benefit outweighs …

Polar chromosomes represent a subset of∼ 7 chromosomes in human cells that first attach
to the mitotic spindle behind the spindle pole. These chromosomes are delayed in …

SUMMARY hPSCs can acquire chromosomal aberrations such as copy number variations
during prolonged maintenance in vitro, conferring growth advantages. However, the effect of …

Publishing in Science, Girish and colleagues achieve chromosome-level genome editing to
reveal a requirement for aneuploidy in breast and melanoma cancers. Authors developed …

Sažetak Chromosomes that first attach to the mitotic spindle behind the spindle pole (ie,
polar) are delayed in alignment and prone to segregation errors. Nevertheless, their …

Culture-acquired variants in human pluripotent stem cells (hPSCs) hinder their applications
in research and clinic. However, the mechanisms that underpin selection of variants remain …