Lamellipodia and ruffles are veil-shaped cell protrusions composed of a highly branched
actin filament meshwork assembled by the Arp2/3 complex. These structures not only …

Formins are a large, evolutionarily old family of cytoskeletal regulators whose roles include
actin cap** and nucleation, as well as modulation of microtubule dynamics. The plant …

The obligate intracellular parasites Toxoplasma gondii and Plasmodium spp. invade host
cells by injecting a protein complex into the membrane of the targeted cell that bridges the …

In the rat testis, studies have shown that cell polarity, in particular spermatid polarity, to
support spermatogenesis is conferred by the coordinated efforts of the Par-, Crumbs-, and …

Formins are major regulators of actin networks. They enhance actin filament dynamics by
remaining processively bound to filament barbed ends. How biochemical and mechanical …

Cancer-associated fibroblasts (CAF) are key regulators of tumorigenesis. Further insights
into the tumor-promoting mechanisms of action of CAFs could help improve cancer …

Objectives Cancer cell migration to secondary organs remains an essential cause of death
among breast cancer (BrCa) patients. Cell motility mainly relies on actin dynamics. Our …

Cell differentiation during spermatogenesis requires a proper actin dynamic, regulated by
several proteins, including formins. Disheveled-Associated-Activator of Morphogenesis1 …

Direct cell-to-cell spreading of Listeria monocytogenes requires the bacteria to induce actin-
based finger-like membrane protrusions in donor host cells that are endocytosed through …

Chloride intracellular channel 4 (CLIC4) is a cytosolic protein implicated in diverse actin-
based processes, including integrin trafficking, cell adhesion, and tubulogenesis. CLIC4 is …