Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle
arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are …

A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific
therapies. Here we show that glucose-mediated changes in gene expression largely persist …

Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

Acute kidney injury (AKI), characterized by a sharp drop in glomerular filtration, continues to
be a significant health burden because it is associated with high initial mortality, morbidity …

The aberrant activation of complement system in several kidney diseases suggests that this
pillar of innate immunity has a critical role in the pathophysiology of renal damage of …

Fibrosis and accumulation of senescent cells are common tissue changes associated with
aging. Here, we show that the CDK inhibitor p21 (CDKN1A), known to regulate the cell cycle …

The renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including ischemia, proteinuria, toxins, and metabolic disorders. It has long been …

Long noncoding RNAs (lncRNAs) have been reported to play an important role in diabetic
nephropathy (DN). However, the molecular mechanism involved in this process remains …