Obesity and bone: a complex relationship
There is a large literature on the relationship between obesity and bone. What we can
conclude from this review is that the increase in body weight causes an increase in BMD …
conclude from this review is that the increase in body weight causes an increase in BMD …
Osteocalcin: a multifaceted bone-derived hormone
G Karsenty - Annual review of nutrition, 2023 - annualreviews.org
Together, loss-and gain-of-function experiments have identified the bone-derived secreted
molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following …
molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following …
Role of leptin in inflammation and vice versa
Inflammation is an essential immune response for the maintenance of tissue homeostasis. In
a general sense, acute and chronic inflammation are different types of adaptive response …
a general sense, acute and chronic inflammation are different types of adaptive response …
Obesity, fat mass and immune system: role for leptin
V Francisco, J Pino, V Campos-Cabaleiro… - Frontiers in …, 2018 - frontiersin.org
Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …
[HTML][HTML] Obesity, osteoporosis and bone metabolism
Obesity and osteoporosis have become major global health problems over the last decades
as their prevalence is increasing. The interaction between obesity and bone metabolism is …
as their prevalence is increasing. The interaction between obesity and bone metabolism is …
Neurovascular coupling in bone regeneration
The mammalian skeletal system is densely innervated by both neural and vascular
networks. Peripheral nerves in the skeleton include sensory and sympathetic nerves. The …
networks. Peripheral nerves in the skeleton include sensory and sympathetic nerves. The …
Leptin resistance: underlying mechanisms and diagnosis
O Gruzdeva, D Borodkina, E Uchasova… - … syndrome and obesity …, 2019 - Taylor & Francis
Leptin and its receptors have been identified as key regulators of body weight and energy
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity …
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity …
Leptin in the interplay of inflammation, metabolism and immune system disorders
V Abella, M Scotece, J Conde, J Pino… - Nature Reviews …, 2017 - nature.com
Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …
Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …
New insights into the biology of osteocalcin
Osteocalcin is among the most abundant proteins in bone and is produced exclusively by
osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies …
osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies …