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Microbiome and human health: current understanding, engineering, and enabling technologies
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …
interrogation of gene function in a wide range of applications and species. In pooled …
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii
Acinetobacter baumannii is a nosocomial Gram-negative pathogen that often displays
multidrug resistance. Discovering new antibiotics against A. baumannii has proven …
multidrug resistance. Discovering new antibiotics against A. baumannii has proven …
Engineering extracellular electron transfer pathways of electroactive microorganisms by synthetic biology for energy and chemicals production
J Zhang, F Li, D Liu, Q Liu, H Song - Chemical Society Reviews, 2024 - pubs.rsc.org
The excessive consumption of fossil fuels causes massive emission of CO2, leading to
climate deterioration and environmental pollution. The development of substitutes and …
climate deterioration and environmental pollution. The development of substitutes and …
A decade of advances in transposon-insertion sequencing
It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS)
methods, which combine genome-wide transposon mutagenesis with high-throughput …
methods, which combine genome-wide transposon mutagenesis with high-throughput …
Phages overcome bacterial immunity via diverse anti-defence proteins
It was recently shown that bacteria use, apart from CRISPR–Cas and restriction systems, a
considerable diversity of phage resistance systems,,–, but it is largely unknown how phages …
considerable diversity of phage resistance systems,,–, but it is largely unknown how phages …
A dual-mechanism antibiotic kills gram-negative bacteria and avoids drug resistance
The rise of antibiotic resistance and declining discovery of new antibiotics has created a
global health crisis. Of particular concern, no new antibiotic classes have been approved for …
global health crisis. Of particular concern, no new antibiotic classes have been approved for …
[HTML][HTML] A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection
The intestinal microbiota provides colonization resistance against pathogens, limiting
pathogen expansion and transmission. These microbiota-mediated mechanisms were …
pathogen expansion and transmission. These microbiota-mediated mechanisms were …
[HTML][HTML] Recent advances in biological approaches towards anode biofilm engineering for improvement of extracellular electron transfer in microbial fuel cells
Over the last two decades, scientific communities have been more interested in turning
organic waste materials into bioenergy. Microbial fuel cells (MFC) can degrade organic …
organic waste materials into bioenergy. Microbial fuel cells (MFC) can degrade organic …
Panning for gold:'model-X'knockoffs for high dimensional controlled variable selection
Many contemporary large-scale applications involve building interpretable models linking a
large set of potential covariates to a response in a non-linear fashion, such as when the …
large set of potential covariates to a response in a non-linear fashion, such as when the …