Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

Synthetic biology has established powerful tools to precisely control cell function.
Engineering these systems to meet clinical requirements has enormous medical …

Cell segregation allows the compartmentalization of cells with similar fates during
morphogenesis, which can be enhanced by cell fate plasticity in response to local molecular …

The vascular barrier that separates blood from tissues is actively regulated by the
endothelium and is essential for transport, inflammation, and haemostasis. Haemodynamic …

Stem cell fate is influenced by specialized microenvironments that remain poorly defined in
mammals,,. To explore the possibility that haematopoietic stem cells derive regulatory …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental
and endogenous stresses and serves to render animals resistant to chemical …

Radiotherapy represents the most effective nonsurgical treatments for gliomas. However,
gliomas are highly radioresistant and recurrence is nearly universal. Results from our …

Abstract Activation of the Hedgehog (Hh) signalling pathway by sporadic mutations or in
familial conditions such as Gorlin's syndrome is associated with tumorigenesis in skin, the …