Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Cancers express a large battery of genes by which they establish an immunosuppressive
tumor microenvironment. Many of these genes are induced by intratumoral hypoxia through …

Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome
for cells to survive hypoxic insults and oxidative stress. They are important during embryonic …

Simple Summary Stereotactic ablative radiotherapy (SABR), which irradiates tumors with
high-dose radiation per fraction, promotes anti-tumor immunity by stimulating various …

Covering 2010–April 2024 There have been tremendous new discoveries and
developments since 2010 in anticancer research based on marine cyanobacteria. Marine …

Gliomas are the most common primary malignant tumors in the central nervous system.
However, conventional treatments, such as surgical resection and postoperative combined …

Cancer cells undergo metabolic reprogramming to survive in hypoxic conditions and meet
the elevated energy demands of the cancer microenvironment. This metabolic alteration is …

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) isomerizes the nearby proline
(Pro) residue when it detects phosphorylated serine (Ser) or threonine (Thr) of target …