Tissue mechanobiology is an emerging field with the overarching goal of understanding the
interplay between biophysical and biochemical responses affecting development …

Inner ear hair cells assemble mechanosensitive hair bundles on their apical surface that
transduce sounds and accelerations. Each hair bundle is comprised of∼ 100 individual …

Hair cells—the sensory cells of the vertebrate inner ear—bear at their apical surfaces a
bundle of actin-filled protrusions called stereocilia, which mediate the cells' …

Background Sensorineural hearing loss is one of the most common sensory deficiencies.
However, the molecular contribution to age-related hearing loss is not fully elucidated …

Hearing loss is a common disorder affecting nearly 20% of the world's population. Recently,
studies have shown that inner ear gene therapy can improve auditory function in several …

Background Ménière's disease (MD) is a disorder of the inner ear that causes episodic bouts
of severe dizziness, roaring tinnitus, and fluctuating hearing loss. To date, no targeted …

Sensory hair cells of the inner ear rely on the hair bundle, a cluster of actin-filled stereocilia,
to transduce auditory and vestibular stimuli into electrical impulses. Because they are long …

In mammals, sound is detected by mechanosensory hair cells that are activated in response
to vibrations at frequency-dependent positions along the cochlear duct. We demonstrate that …

Assembly of actin-based stereocilia is critical for cochlear hair cells to detect sound. To tune
their mechanosensivity, stereocilia form bundles composed of graded rows of ascending …

The roles of keratan sulfate (KS) as a proton detection glycosaminoglycan in neurosensory
processes in the central and peripheral nervous systems is reviewed. The functional …