The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

Controversy surrounds reports describing the derivation of human trophoblast cells from
placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

BACKGROUND: MicroRNAs (miRNAs) are small single-stranded RNA molecules working
as post-transcriptional modulators of gene expression. Trophoblast cells are a heterogenous …

Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an
estimation of the relative contribution of genetic and shared and nonshared environmental …

The use of in vitro tools to study trophoblast differentiation and function is essential to
improve understanding of normal and abnormal placental development. The relative …

Background The extent to which development-and age-associated epigenetic changes are
influenced by genetic, environmental and stochastic factors remains to be discovered. Twins …

Background The human placenta facilitates the exchange of nutrients, gas and waste
between the fetal and maternal circulations. It also protects the fetus from the maternal …