Hydrogel drug delivery systems for minimally invasive local immunotherapy of cancer

AS Mikhail, R Morhard, M Mauda-Havakuk… - Advanced drug delivery …, 2023 - Elsevier
Although systemic immunotherapy has achieved durable responses and improved survival
for certain patients and cancer types, low response rates and immune system-related …

A methylation-and immune-related lncRNA signature to predict ovarian cancer outcome and uncover mechanisms of chemoresistance

L Chen, W Gao, L Lin, C Sha, T Li, Q Chen… - Journal of Ovarian …, 2023 - Springer
Tumor-associated lncRNAs regulated by epigenetic modification switches mediate immune
escape and chemoresistance in ovarian cancer (OC). However, the underlying mechanisms …

High Ki67 gene expression is associated with aggressive phenotype in hepatocellular carcinoma

V Ramos-Santillan, M Oshi, E Nelson… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Background Hepatocellular carcinoma (HCC) with high Ki67 protein expression, the most
commonly used cell proliferation marker, is associated with an aggressive biologic …

Gastric cancer with enhanced myogenesis is associated with less cell proliferation, enriched epithelial-to-mesenchymal transition and angiogenesis, and poor clinical …

K Chida, M Oshi, N An, H Kanazawa… - American Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Gastric cancer (GC) remains a lethal disease, with over 26,000 new cases and more than
11,000 deaths annually in the US. Thus, a deeper understanding of GC biology is critical to …

E2F target score is associated with cell proliferation and survival of patients with hepatocellular carcinoma

K Chida, M Oshi, AM Roy, T Yachi, M Nara, K Yamada… - Surgery, 2023 - Elsevier
Background E2F target genes are essential for the cell cycle. A score that quantifies its
activity is expected to reflect the aggressiveness and prognosis of hepatocellular carcinoma …

Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer

S Qin, H **, Y Li, X Chen, J He, J **ao, Y Qin… - Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is a critical m6A reader. It
encodes proteins that contain several KH domains, which are important in RNA binding …

Pancreatic ductal adenocarcinoma with a high expression of alcohol dehydrogenase 1B is associated with less aggressive features and a favorable prognosis

K Chida, M Oshi, AM Roy, T Sato… - American Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Alcohol dehydrogenase (ADH) oxidizes alcohol into acetaldehyde (AA), which is a known
carcinogen. Aldehyde dehydrogenase (ALDH) oxidizes AA into acetate. Therefore …

High miR-200c expression is associated with suppressed epithelial-mesenchymal transition, TGF-β signaling and better survival despite enhanced cell proliferation in …

K Shichiri, M Oshi, D Ziazadeh, I Endo… - American journal of …, 2023 - pmc.ncbi.nlm.nih.gov
MicroRNAs are small non-coding RNAs that epigenetically regulate gene expression. MiR-
200c is a known tumor suppressive microRNA found in many types of cancer, and its high …

RAD51 High-Expressed Hepatocellular Carcinomas are Associated With High Cell Proliferation

K Takahashi, L Yan, N An, K Chida, W Tian… - Journal of Surgical …, 2024 - Elsevier
Introduction RAD51 is a pivotal DNA repair gene managing double-stranded DNA break
recognition and repair. RAD51 high expression was associated with adverse outcomes in …

Angiogenesis Is Associated With Aggressive Biology That Counterbalances With Tumor Immunogenicity in Hepatocellular Carcinoma

R Vaghjiani, R Wu, KH Tung, T Ishikawa… - World Journal of …, 2025 - wjon.elmerpub.com
Background: Hepatocellular carcinoma (HCC) is an arterialized tumor; thus, anti-
angiogenesis targeted therapy is in clinical practice. Herein, we hypothesized that HCC with …